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CI-SCREEN
CI-Screen | Customized cell immortalization | Go to ... |
Physiologically relevant cells
The major challenge of the drug development process is the low success rate. To exclude inappropriate compounds early in the development process, test conditions with a high biological relevance are required. Primary cells are currently the best in vitro model that resembles the in vivo condition. Due to their limited proliferation capacity they cannot be used for large scale screenings and are also limited for ADME/Tox tests.
The CI-SCREEN technology is an enabling tool. It creates biologically relevant cell systems in sufficient numbers to perform drug development and toxicity testing campaigns.
The CI-SCREEN technology aims at the pivotal reason for the limited availability of primary cells – the limited proliferation capacity. To overcome this natural bottleneck the CI-SCREEN technology implements expansion genes into freshly isolated primary cells of the desired tissue. Thereby the primary cells are amplified to cell numbers enabling reliable and reproducible drug testing campaigns. Importantly, due to our expansion technology the cells behave like their “normal” counterparts and enable a screening in a biologically relevant setting.
CI-SCREEN has been validated for different cell types:
• endothelial cells | Datasheet |
• epithelial cells
• keratinocytes
• chondrocytes
• osteoblasts
.. and for different species as well as patients (donors):
• human
• bovine
• rat
• murine
Please contact us to learn about this technology and to obtain non-confidential data.
Customized cell immortalization
Depending on the field of indication our customers develop drugs for, InSCREENeX offers the establishment of relevant primary cells. CI-SCREEN can be applied to the primary cell material of your choice:
• various cell types
• preclinical disease model
• patient specific cells
• disease specific cells