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CI-SCREEN
CI-Screen | Cells on demand | Go to ... |
Overview
The major challenge of the drug development process is the low success rate. To exclude inappropriate compounds early in the development process, test conditions with a high biological relevance are required. Primary cells are currently the best in vitro model that resembles the in vivo condition. Due to their limited proliferation capacity they cannot be used for large scale screenings and are also limited for ADME/Tox tests.
The CI-SCREEN technology is an enabling tool. It creates biologically relevant cell systems in sufficient numbers to perform drug development and toxicity testing campaigns.
The CI-SCREEN technology aims at the pivotal reason for the limited availability of primary cells – the limited proliferation capacity. To overcome this natural bottleneck the CI-SCREEN technology implements expansion genes into freshly isolated primary cells of the desired tissue. Thereby the primary cells are amplified to cell numbers enabling reliable and reproducible drug testing campaigns. Importantly, due to our expansion technology the cells behave like their “normal” counterparts and enable a screening in a biological relevant setting.
Please contact us to learn about this technology.
Cells on demand
Depending on the field of indication our customers develop drugs for, InSCREENeX offers the establishment of relevant primary cells. | Click for request |